Collet E, Petit J M, Lacroix M, Bensa A F, Morvan C, Lambert D
Service de Dermatologie, Hôpital du Bocage, Dijon.
Ann Dermatol Venereol. 1995;122(6-7):413-6.
Chronic urticaria results from multiple interactive causes. For certain authors dythyroidism is significantly more frequent in patients with chronic urticaria, often associated with other autoimmune disorders.
This study included 45 patients with chronic urticaria (29 men and 16 women, mean age 45.6 years). All underwent clinical examination for thyroid disease with assay of free T3 and T4, ultrasensitive TSH and antimicrosome and antithyroperoxidase antithyroid antibodies.
Among the 45 patients, 8, all women, had an autoimmune thyroid disease: Graves' disease (n = 1), juvenile chronic thyroiditis (n = 1), autoimmune disease n = 6). All had goiter but most had no clinical sign suggestive of hypothyroidism or hyperthyroidism. Other clinical features or laboratory findings suggested autoimmune disorders in 3.
These results suggest that a complete thyroid examination with hormone assay, especially in women, should be performed in patients with chronic urticaria. TSH and antiperoxidase antibodies appear to be the most sensitive and specific assays in patients with autoimmune thyroid disease.
慢性荨麻疹由多种相互作用的病因引起。对于某些作者而言，甲状腺功能紊乱在慢性荨麻疹患者中明显更为常见，且常与其他自身免疫性疾病相关。
本研究纳入了45例慢性荨麻疹患者（29例男性和16例女性，平均年龄45.6岁）。所有患者均接受了甲状腺疾病的临床检查，包括检测游离T3和T4、超敏促甲状腺激素以及抗微粒体和抗甲状腺过氧化物酶抗甲状腺抗体。
在45例患者中，8例均为女性，患有自身免疫性甲状腺疾病：格雷夫斯病（n = 1）、青少年慢性甲状腺炎（n = 1）、自身免疫性疾病（n = 6）。所有患者均有甲状腺肿大，但大多数患者无提示甲状腺功能减退或亢进的临床体征。另外3例患者的其他临床特征或实验室检查结果提示存在自身免疫性疾病。
这些结果表明，对于慢性荨麻疹患者，尤其是女性，应进行包括激素检测在内的全面甲状腺检查。促甲状腺激素和抗过氧化物酶抗体似乎是自身免疫性甲状腺疾病患者中最敏感和特异的检测方法。
