Lee J S, Kawakubo K, Kashihara H, Mori K
Department of Health Promotion Sciences, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
Int J Obes Relat Metab Disord. 2004 Mar;28(3):391-5. doi: 10.1038/sj.ijo.0802568.
To elucidate the effect of long-term body weight changes on the subsequent incidence of hypertension in a large sample of community-residing Japanese males and females.
Subjects were 3431 men and 2409 women, between 30 and 69 y old, who underwent annual periodic health examinations from 1987 (baseline year) until 1996. They were free from hypertension during the first 5 y from the baseline year. Body weight change index between 1987 and 1992 was the body mass index (BMI) (weight (kg) over height (m) squared) slope. Multiple logistic analysis was performed to assess the effect of BMI slope on the incidence of hypertension during the subsequent 5 ys (1992-1996), while controlling for baseline age, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP) and smoking habit.
During the first 5 y, the prevalence of overweight males (25.0< or =BMI<30.0) significantly increased from 18.4 to 23.5% in males and from 10.4 to 14.1% in females. In all, 11.7% of the males and 8.9% of the females developed hypertension between 1992 and 1996. Those who developed hypertension had a significantly higher baseline age, BMI, SBP and DBP both in males and females. The baseline smoking rate among the females who developed hypertension was significantly lower than those who did not develop the hypertension. After adjustment of these covariables by the multiple logistic analysis, the BMI slope was positively correlated with the incidence of hypertension both in females and males significantly.
Weight gain increased the risk of developing hypertension independent of age and blood pressure level among relatively lean Japanese men and women.
阐明在大量居住于社区的日本男性和女性样本中，长期体重变化对随后高血压发病率的影响。
研究对象为3431名男性和2409名女性，年龄在30至69岁之间，他们从1987年（基线年）至1996年接受年度定期健康检查。在基线年开始的前5年里他们没有高血压。1987年至1992年期间的体重变化指数是体重指数（BMI）（体重（千克）除以身高（米）的平方）斜率。进行多因素逻辑分析以评估BMI斜率对随后5年（1992 - 1996年）高血压发病率的影响，同时控制基线年龄、BMI、收缩压（SBP）、舒张压（DBP）和吸烟习惯。
在最初5年中，超重男性（25.0≤BMI＜30.0）的患病率在男性中从18.4%显著增加至23.5%，在女性中从10.4%增加至14.1%。总体而言，在1992年至1996年期间，11.7%的男性和8.9%的女性患了高血压。患高血压的男性和女性在基线时年龄、BMI、SBP和DBP均显著更高。患高血压的女性的基线吸烟率显著低于未患高血压的女性。通过多因素逻辑分析对这些协变量进行调整后，BMI斜率与男性和女性的高血压发病率均显著正相关。
在相对瘦的日本男性和女性中，体重增加会增加患高血压的风险，且独立于年龄和血压水平。
