年龄和体重指数对中国健康与营养调查中高血压亚型发病率的联合影响：一项为期22年的队列研究

Joint effects of age and body mass index on the incidence of hypertension subtypes in the China Health and Nutrition Survey: A cohort study over 22years.

作者信息

Qi Su-Fen, Zhang Bing, Wang Hui-Jun, Yan Jing, Du Pei, Zhang Wei, Mi Ying-Jun, Zhao Jing-Jing, Liu Dian-Wu, Tian Qing-Bao

机构信息

Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, China.

出版信息

Prev Med. 2016 Aug;89:23-30. doi: 10.1016/j.ypmed.2016.05.004. Epub 2016 May 4.

DOI:10.1016/j.ypmed.2016.05.004

PMID:27155441

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6443580/

Abstract

OBJECTIVES

We seek to investigate the joint effects of age and body mass index (BMI) on the incident hypertension subtypes among Chinese adults during 1989-2011.

METHODS

We investigated the Incidence rates (IRs, per 100person-years) of hypertension subtypes, adjusted relative risks (RRs) and population attributable risk percent (PAR%) of BMI for hypertension, and clarified the age-specific effect of BMI on incident hypertension utilizing a dynamic cohort study from the China Health and Nutrition Survey (CHNS) 1989-2011.

RESULTS

Normotensive participants (n=53,028) at baseline were included, with mean age was 41.7 (95% CI, 41.6-41.7)years old. During a total of 118,694person years (average was 6.38years) of follow-up, a total of 5208 incident cases of hypertension were documented. The IRs of hypertension were 4.4 (95% CI, 4.3-4.5), which increased gradually by age and BMI (Ptrend<0.001). Compared with those with BMI<22kg/m(2), the RR of hypertension was 3.13 (95% CI, 2.84-3.45) in the group with BMI≥28kg/m(2). The PAR% (BMI>22 vs. BMI<22) for hypertension in Chinese population was 32% (95% CI, 29-34%). Similar trends were observed in all age and BMI groups for both isolated systolic hypertension and systolic-diastolic hypertension, which were mainly affected by age. In contrast, the peak IR of isolated diastolic hypertension was observed in participants aged 30-49years with higher BMIs.

CONCLUSIONS

The PAR% (IR of BP≥140/90 or treatment for BMI>22 vs. IR for BMI<22) of elevated body weight for hypertension was 32% in Chinese population.

摘要

目的

我们旨在研究1989年至2011年期间年龄和体重指数（BMI）对中国成年人高血压亚型发病的联合影响。

方法

我们利用1989年至2011年中国健康与营养调查（CHNS）的动态队列研究，调查了高血压亚型的发病率（IR，每100人年）、BMI对高血压的调整相对风险（RR）和人群归因风险百分比（PAR%），并阐明了BMI对高血压发病的年龄特异性影响。

结果

纳入基线时血压正常的参与者（n = 53,028），平均年龄为41.7（95%CI，41.6 - 41.7）岁。在总共118,694人年（平均6.38年）的随访期间，共记录了5208例高血压发病病例。高血压的发病率为4.4（95%CI，4.3 - 4.5），随年龄和BMI逐渐增加（Ptrend<0.001）。与BMI<22kg/m²的人群相比，BMI≥28kg/m²组的高血压RR为3.13（95%CI，2.84 - 3.45）。中国人群中BMI>22与BMI<22相比，高血压的PAR%为32%（95%CI，29 - 34%）。在所有年龄和BMI组中，单纯收缩期高血压和收缩期-舒张期高血压均观察到类似趋势，主要受年龄影响。相比之下，单纯舒张期高血压的发病率峰值出现在BMI较高的30 - 49岁参与者中。