弓形虫与精神分裂症。
Toxoplasma gondii and schizophrenia.
作者信息
Torrey E Fuller, Yolken Robert H
机构信息
Stanley medical REsearch Institute, Bethesda, Maryland 20814-2142, USA.
出版信息
Emerg Infect Dis. 2003 Nov;9(11):1375-80. doi: 10.3201/eid0911.030143.
Recent epidemiologic studies indicate that infectious agents may contribute to some cases of schizophrenia. In animals, infections with Toxoplasma gondii can alter behavior and neurotransmitter function. In humans, acute infection with T. gondii can produce psychotic symptoms similar to those displayed by persons with schizophrenia. Since 1953, a total of 19 studies of T. gondii antibodies in persons with schizophrenia and other severe psychiatric disorders and in controls have been reported; 18 reported a higher percentage of antibodies in the affected persons; in 11 studies the difference was statistically significant. Two other studies found that exposure to cats in childhood was a risk factor for the development of schizophrenia. Some medications used to treat schizophrenia inhibit the replication of T. gondii in cell culture. Establishing the role of T. gondii in the etiopathogenesis of schizophrenia might lead to new medications for its prevention and treatment.
近期的流行病学研究表明，感染因素可能在某些精神分裂症病例中起作用。在动物身上，感染弓形虫会改变行为和神经递质功能。在人类中，急性感染弓形虫可产生与精神分裂症患者相似的精神病症状。自1953年以来，共报告了19项针对精神分裂症患者、其他严重精神疾病患者及对照人群的弓形虫抗体研究；18项研究报告称，患病者体内抗体比例更高；11项研究中，这种差异具有统计学意义。另外两项研究发现，儿童时期接触猫是精神分裂症发病的一个风险因素。一些用于治疗精神分裂症的药物在细胞培养中可抑制弓形虫的复制。确定弓形虫在精神分裂症病因学中的作用可能会带来预防和治疗该病的新药物。
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