控制食物摄入量并使用含有2%柠檬酸锌和0.3%三氯生的牙膏后的牙菌斑抗菌水平。
Plaque antibacterial levels following controlled food intake and use of a toothpaste containing 2% zinc citrate and 0.3% Triclosan.
作者信息
Hall P J, Green A K, Horay C P, de Brabander S, Beasley T J, Cromwell V J, Holt J S, Savage D J
机构信息
Unilever Oral Care, Quarry Road East, Bebington, Wirral, UK.
出版信息
Int Dent J. 2003 Dec;53(6 Suppl 1):379-84. doi: 10.1111/j.1875-595x.2003.tb00913.x.
OBJECTIVES
To measure the levels of zinc and Triclosan present in plaque 12 hours post-brushing and following two weeks home use of a toothpaste formulation containing 2% zinc citrate and 0.3% Triclosan. To measure the levels of zinc and Triclosan in plaque following two weeks home use of the test toothpaste formulation together with a further morning's brushing and a day of controlled food intake.
METHODS
A total of 104 subjects completed the study. Plaque samples were taken before use of the test toothpaste and again after a specified regime of product use and food intake. The samples were analysed for zinc or Triclosan.
RESULTS
Levels of zinc and Triclosan in plaque 12 hours after last brushing and following a 2-week home usage of product, were 149.1 microg/g and 8.6 microg/g respectively. Following a morning brushing and a day of controlled food intake zinc and Triclosan levels were 94.7 microg/g and 4.1 microg/g respectively. These levels of agents were found to reduce pH drop in vitro.
CONCLUSIONS
Regular use of a toothpaste containing 2% zinc citrate and 0.3% Triclosan can lead to a build-up of antibacterial agents in plaque that continue to work even after controlled food intake.
目的
测量刷牙12小时后以及在家中使用含2%柠檬酸锌和0.3%三氯生的牙膏配方两周后的牙菌斑中锌和三氯生的含量。测量在使用测试牙膏配方两周并额外进行一个早晨的刷牙以及一天的控制饮食摄入后牙菌斑中锌和三氯生的含量。
方法
共有104名受试者完成了该研究。在使用测试牙膏前以及在规定的产品使用和饮食摄入方案后再次采集牙菌斑样本。对样本进行锌或三氯生分析。
结果
在最后一次刷牙12小时后以及在家中使用产品两周后，牙菌斑中锌和三氯生的含量分别为149.1微克/克和8.6微克/克。在进行一个早晨的刷牙和一天的控制饮食摄入后，锌和三氯生的含量分别为94.7微克/克和4.1微克/克。发现这些药剂的含量可降低体外的pH值下降。
结论
经常使用含2%柠檬酸锌和0.3%三氯生的牙膏会导致牙菌斑中抗菌剂的积累，即使在控制饮食摄入后仍能继续发挥作用。
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