Hindsén Monica, Isaksson Marléne, Persson Lena, Zimersson Erik, Bruze Magnus
Department of Occupationa and Enviromental Dermatology, Malmö Universty Hospital, Malmö, Sweden.
J Am Acad Dermatol. 2004 Feb;50(2):215-9. doi: 10.1016/j.jaad.2003.07.007.
Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen.
We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects.
We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects with thin-layer chromatography, high-pressure liquid chromatography, and gas chromatography-mass spectrometry.
Photoallergy was demonstrated to ketoprofen, which was detected in personal objects.
Relapses of photoallergic contact dermatitis in patients photoallergic to ketoprofen can be induced by ketoprofen-contaminated objects such as bandages and slippers.
自20世纪80年代中期以来，已认识到酮洛芬引起的光变应性接触性皮炎。据报道，停用酮洛芬后皮肤反应会持续数周。一个原因可能是皮肤中残留的酮洛芬，这已在皮肤活检标本中得到证实。
我们试图报告3例因局部抗炎凝胶中的酮洛芬引起的光变应性接触性皮炎病例，以及使用受酮洛芬污染的物品后出现的皮炎复发情况。
我们用标准系列对抗炎凝胶、酮洛芬及其成分进行了连续稀释后的斑贴试验和光斑贴试验，并对个人物品提取物进行了测试。我们用薄层色谱法、高压液相色谱法和气相色谱-质谱法对个人物品进行了化学研究。
证明对酮洛芬存在光过敏，且在个人物品中检测到了酮洛芬。
对酮洛芬光过敏的患者，光变应性接触性皮炎的复发可由受酮洛芬污染的物品如绷带和拖鞋诱发。
