Chaput Nathalie, Taïeb Julien, Schartz Noël E C, André Fabrice, Angevin Eric, Zitvogel Laurence
ERIT-M 02-08 INSERM, Department of Clinical Biology, Institut Gustave Roussy (IGR), 39 rue Camille Desmoulins, 94805, Villejuif, France.
Cancer Immunol Immunother. 2004 Mar;53(3):234-9. doi: 10.1007/s00262-003-0472-x. Epub 2004 Jan 16.
Exosomes are small membrane vesicles originating from late endosomes and secreted by hematopoietic and epithelial cells in culture. Exosome proteic and lipid composition is unique and might shed some light into exosome biogenesis and function. Exosomes secreted from professional antigen-presenting cells (i.e., B lymphocytes and dendritic cells) are enriched in MHC class I and II complexes, costimulatory molecules, and hsp70-90 chaperones, and have therefore been more extensively studied for their immunomodulatory capacities in vitro and in vivo. This review will present the main biological features pertaining to tumor or DC-derived exosomes, will emphasize their immunostimulatory function, and will discuss their implementation in cancer immunotherapy.
外泌体是源自晚期内体的小膜泡，由培养中的造血细胞和上皮细胞分泌。外泌体的蛋白质和脂质组成独特，可能有助于揭示外泌体的生物发生和功能。专业抗原呈递细胞（即B淋巴细胞和树突状细胞）分泌的外泌体富含MHC I类和II类复合物、共刺激分子和hsp70 - 90伴侣蛋白，因此在体外和体内的免疫调节能力方面得到了更广泛的研究。本综述将介绍与肿瘤或树突状细胞衍生的外泌体相关的主要生物学特征，强调其免疫刺激功能，并讨论它们在癌症免疫治疗中的应用。
