Nedal A, Zotchev S B
Department of Biotechnology, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Appl Microbiol Biotechnol. 2004 Mar;64(1):7-15. doi: 10.1007/s00253-003-1535-9. Epub 2004 Jan 16.
Deoxyaminosugars comprise an important class of deoxysugars synthesized by a variety of different microorganisms; they can be structural components of lipopolysaccharides, extracellular polysaccharides, and secondary metabolites such as antibiotics. Genes involved in the biosynthesis of the deoxyaminosugars are often clustered and are located in the vicinity of other genes required for the synthesis of the final compound. Most of the gene clusters for aminosugar biosynthesis have common features, as they contain genes encoding dehydratases, isomerases, aminotransferases, methyltransferases, and glycosyltransferases. In the present mini-review, the proposed biosynthetic pathways for deoxyaminosugar components of both macrolide and non-macrolide antibiotics are highlighted. The possibilities for genetic manipulations of the deoxyaminosugar biosynthetic pathways aimed at production of novel secondary metabolites are discussed.
脱氧氨基糖是由多种不同微生物合成的一类重要的脱氧糖；它们可以是脂多糖、细胞外多糖以及抗生素等次级代谢产物的结构成分。参与脱氧氨基糖生物合成的基因通常成簇存在，且位于合成最终化合物所需的其他基因附近。大多数氨基糖生物合成的基因簇具有共同特征，因为它们包含编码脱水酶、异构酶、氨基转移酶、甲基转移酶和糖基转移酶的基因。在本综述中，重点介绍了大环内酯类和非大环内酯类抗生素的脱氧氨基糖成分的拟议生物合成途径。讨论了针对新型次级代谢产物生产对脱氧氨基糖生物合成途径进行基因操作的可能性。
