Smith Barry, Williams Jennifer, Schulze-Kremer Steffen
Institute for Formal Ontology and Medical Information Science, University of Leipzig.
AMIA Annu Symp Proc. 2003;2003:609-13.
The rapidly increasing wealth of genomic data has driven the development of tools to assist in the task of representing and processing information about genes, their products and their functions. One of the most important of these tools is the Gene Ontology (GO), which is being developed in tandem with work on a variety of bioinformatics databases. An examination of the structure of GO, however, reveals a number of problems, which we believe can be resolved by taking account of certain organizing principles drawn from philosophical ontology. We shall explore the results of applying such principles to GO with a view to improving GO's consistency and coherence and thus its future applicability in the automated processing of biological data.
基因组数据的迅速增长推动了相关工具的开发，以协助呈现和处理有关基因、其产物及其功能的信息。其中最重要的工具之一是基因本体论（Gene Ontology，简称GO），它是与各种生物信息学数据库的工作同步开发的。然而，对GO结构的审视揭示了一些问题，我们认为通过考虑从哲学本体论中汲取的某些组织原则可以解决这些问题。我们将探讨应用这些原则于GO的结果，以期提高GO的一致性和连贯性，从而提升其在生物数据自动化处理中的未来适用性。
