Steckel H, Mindermann-Nogly F
Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Kiel, Germany.
Eur J Pharm Biopharm. 2004 Jan;57(1):107-14. doi: 10.1016/s0939-6411(03)00156-5.
Chitosan pellets were successfully prepared using the extrusion/spheronization technology. Microcrystalline cellulose was used as additive in concentrations from 70 to 0%. The powder mixtures were extruded using water and diluted acetic acid solution in different powder to liquid ratios. The effects on bead formation using water and different acetic acid concentrations and solution quantities were analysed. Also, the morphological and mechanical characteristics of the obtained beads were investigated. With demineralized water as granulation fluid, pellets with a maximum of 50% (m/m) of chitosan could be produced. The mass fraction of chitosan within the pellets could be increased to 100% by using diluted acetic acid for the granulation step.
采用挤出滚圆技术成功制备了壳聚糖微丸。微晶纤维素用作添加剂，浓度范围为70%至0%。将粉末混合物以不同的粉液比用水和稀释的醋酸溶液进行挤出。分析了用水、不同醋酸浓度和溶液量对微丸形成的影响。此外，还研究了所得微丸的形态和机械特性。以去离子水作为制粒液时，可制备壳聚糖含量最高为50%（质量/质量）的微丸。通过在制粒步骤中使用稀释的醋酸，微丸中壳聚糖的质量分数可提高至100%。
