Bogden J D
Department of Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School, PO Box 1709, Newark, NJ 07101-1709, USA.
J Nutr Health Aging. 2004;8(1):48-54.
There is compelling evidence that demonstrates that severe zinc deficiency can cause substantial impairment of cellular immunity which can result in infection and even death. The effects on immunity of mild to moderate zinc deficiency are considerably less severe and may be subtle. Zinc supplementation, especially in combination with other micronutrients, can enhance immunity if an underlying deficiency is present. Supplementation with zinc as a single nutrient, especially at high doses, can have adverse effects that include interfering with copper nutriture and impairment of immune functions.
有确凿证据表明，严重缺锌会导致细胞免疫功能严重受损，进而引发感染甚至死亡。轻度至中度缺锌对免疫功能的影响则要轻得多，可能较为隐匿。如果存在潜在的锌缺乏，补充锌，尤其是与其他微量营养素联合补充时，可增强免疫力。单独补充锌，尤其是高剂量时，可能会产生不良影响，包括干扰铜的营养状况和损害免疫功能。
