Wouters-Wesseling W, Vos A P, Van Hal M, De Groot L C P G M, Van Staveren W A, Bindels J G
Numico Research B.V., Department of Clinical Nuttrition and Diets, P.O. Box 7005, 6700 CA Wageningen, The Netherlands.
J Nutr Health Aging. 2005 Jul-Aug;9(4):281-6.
Ageing induces a change in immune responses. Besides this, impaired nutritional status is considered to have a critical influence on immune function, which may be reversed by nutritional supplementation. We evaluated the effect of an enriched drink on immune function in the elderly. 33 frail elderly subjects (aged > or = 65 years and body mass index < or = 25) received two 125 ml packages of either an enriched drink (n=20) or placebo (n=13) daily for 6 months. The enriched drink contained macro- and micronutrients. At baseline and after 6 months blood samples were drawn and PBMC's were isolated. ConA stimulated proliferation and IL-2 production of PBMC's were measured. There was a significant difference between groups in proliferation over the study period. The supplement group remained stable whereas the placebo group showed a reduction in proliferation over the 6-month period. There was no significant difference in IL-2 production between groups. Our study adds to the evidence that nutritional supplementation can affect immune function in the elderly.
衰老会引发免疫反应的变化。除此之外，营养状况受损被认为对免疫功能有至关重要的影响，而营养补充可能会逆转这种影响。我们评估了一种强化饮品对老年人免疫功能的作用。33名体弱的老年受试者（年龄≥65岁且体重指数≤25）每天接受两包125毫升的饮品，其中20名受试者饮用强化饮品，13名受试者饮用安慰剂，为期6个月。强化饮品含有大量营养素和微量营养素。在基线期和6个月后采集血样并分离外周血单个核细胞（PBMC）。测量了刀豆蛋白A刺激的PBMC增殖和白细胞介素-2的产生。在研究期间，两组之间的增殖存在显著差异。补充组保持稳定，而安慰剂组在6个月期间增殖减少。两组之间白细胞介素-2的产生没有显著差异。我们的研究进一步证明了营养补充会影响老年人的免疫功能。
