暴露不当：端粒失去保护时的情况。
Indecent exposure: when telomeres become uncapped.
作者信息
Ferreira Miguel Godinho, Miller Kyle M, Cooper Julia Promisel
机构信息
Telomere Biology Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.
出版信息
Mol Cell. 2004 Jan 16;13(1):7-18. doi: 10.1016/s1097-2765(03)00531-8.
Abstract
The protective "cap" that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the pathways that lead from telomere dysfunction to chromosomal catastrophe.
摘要
在染色体末端组装的保护性“帽”招募并控制着一个复杂的生化活动网络，其中每一个活动对于端粒结构和基因组稳定性的维持都至关重要。最近的研究揭示了端粒帽的组成成分，并开始明确从端粒功能障碍到染色体灾难的途径。
Zotero 插件