Brodsky F M
Department of Pharmacy, University of California, San Francisco, CA 94143-0446, USA.
Trends Cell Biol. 1992 Apr;2(4):109-15. doi: 10.1016/0962-8924(92)90015-f.
Stimulation of helper T cells by class II molecules occurs when the class II molecules bind and display peptides derived from foreign antigens that have been endocytosed. The formation of peptide-class II complexes requires antigen degradation and exposure of the peptide-binding site of class II molecules, both of which depend on proteolysis and low pH in the endocytic pathway. This review discusses the role of specific compartments of the endocytic pathway in the generation of antigenic peptides, and in the binding of antigenic peptides to newly synthesized class II molecules and those that are internalized from the cell surface.
当II类分子结合并呈递源自已被内吞的外来抗原的肽段时，会发生辅助性T细胞被II类分子刺激的情况。肽 - II类复合物的形成需要抗原降解以及II类分子肽结合位点的暴露，这两者都依赖于内吞途径中的蛋白水解作用和低pH环境。本综述讨论了内吞途径中特定区室在抗原肽产生、抗原肽与新合成的II类分子以及从细胞表面内化的II类分子结合过程中的作用。
