Harding C V
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Trends Cell Biol. 1995 Mar;5(3):105-9. doi: 10.1016/s0962-8924(00)88959-x.
Phagocytosis plays a major role in the defence of higher organisms against microbial infection not only by allowing ingested microbes to be destroyed by microbicidal mechanisms, but also by providing the basis for processing of their antigens to forms that generate immune responses. This article examines the role of the phagolysosome in antigen processing, and discusses the contributions of both MHC class II and MHC class I molecules to the presentation of antigens derived from phagocytosed material.
吞噬作用在高等生物抵御微生物感染的防御过程中发挥着重要作用，这不仅是因为它能使摄入的微生物通过杀菌机制被破坏，还因为它为将微生物抗原加工成能引发免疫反应的形式提供了基础。本文探讨了吞噬溶酶体在抗原加工中的作用，并讨论了MHC II类分子和MHC I类分子在呈递源自吞噬物质的抗原方面所起的作用。
