College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
Immune Netw. 2011 Dec;11(6):412-5. doi: 10.4110/in.2011.11.6.412. Epub 2011 Dec 31.
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2K(b)-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
竹红菌素 A 近年来由于其光诱导的抗肿瘤、抗真菌和抗病毒活性而备受关注。在这里，我们报告竹红菌素 A 对 MHC 限制性抗原呈递具有免疫调节作用。竹红菌素 A 抑制树突状细胞中外源抗原的 II 类 MHC 限制性呈递，但不抑制外源抗原的 I 类 MHC 限制性呈递。竹红菌素 A 还抑制内源性抗原呈递的细胞质途径。然而，竹红菌素 A 并不抑制树突状细胞（DCs）上 I 类和 II 类 MHC 分子的表达、DCs 的吞噬活性，或 H-2K(b)-限制性合成肽 SIINFEKL 的呈递。这些结果表明，竹红菌素 A 差异调节 MHC 限制性抗原呈递途径。
