Layegh Pouran, Mojahedi Mohammad Javad, Malekshah Parisa Emamgholi Tabar, Pezeshkpour Fakhrozaman, Vahedian Mohamad, Nazemian Fatemeh, Pour Farzaneh Sharifi
Department of Dermatology, Qaem Hospital, Mashad University of Medical Sciences, Mashad, Iran.
Indian J Dermatol Venereol Leprol. 2007 Jul-Aug;73(4):231-4. doi: 10.4103/0378-6323.32887.
Renal itch is a relatively common and distressing problem for patients with chronic renal failure. Granisetron, is a potent and selective inhibitor of 5-HT3 receptors. There have been some studies about the effect of ondansetron in uremic pruritus and one case report has recently described relief of renal itch with granisetron.
To evaluate the effect of Granisetron on uremic pruritus in Continuous Ambulatory Peritoneal Dialysis (CAPD) and Hemodialysis (HD) patients.
To study the prevalence of uremic pruritus, patients on CAPD and HD were asked to complete a pruritus questionnaire. Their replies were scored based on numerical scales. Pruritus was graded, according to the total points for each patient, as mild, moderate or severe. Fourteen patients with moderate to severe pruritus were enrolled in the trial. During treatment, patients received granisetron (1 mg tablet twice a day P.O), for a period of 1 month. They were asked to score the severity of pruritus twice a day.
Seventy seven percent of the patients responded to the treatment and at 1 st, 2 nd and 4 th week the mean values of the pruritus scores were 23, 16 and 8 points respectively. Before starting treatment the score was 31 points (P =0.03). Weekly clinical and laboratory examination showed no important side effects.
Granisetron might be an effective, safe and well tolerated drug for the treatment of uremic pruritus.
肾性瘙痒是慢性肾衰竭患者相对常见且令人苦恼的问题。格拉司琼是一种强效且选择性的5 - HT3受体抑制剂。关于昂丹司琼对尿毒症瘙痒的影响已有一些研究，最近有一例报告描述了格拉司琼缓解肾性瘙痒的情况。
评估格拉司琼对持续非卧床腹膜透析（CAPD）和血液透析（HD）患者尿毒症瘙痒的疗效。
为研究尿毒症瘙痒的患病率，要求CAPD和HD患者完成一份瘙痒问卷。根据数字量表对他们的回答进行评分。根据每位患者的总分将瘙痒分为轻度、中度或重度。14例中度至重度瘙痒患者纳入试验。治疗期间，患者口服格拉司琼（1毫克片剂，每日两次），为期1个月。要求他们每天对瘙痒严重程度进行两次评分。
77%的患者对治疗有反应，在第1、2和4周时，瘙痒评分的平均值分别为23分、16分和8分。治疗开始前评分为31分（P = 0.03）。每周的临床和实验室检查显示无重要副作用。
格拉司琼可能是一种治疗尿毒症瘙痒有效、安全且耐受性良好的药物。
