毛萼香茶菜中的细胞毒性二萜类化合物。

Cytotoxic diterpenoids from Isodon enanderianus.

作者信息

Xiang Wei, Na Zhi, Li Sheng-Hong, Li Ma-Lin, Li Rong-Tao, Tian Qin-E, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Academia Sinica, Kunming, PR China.

出版信息

Planta Med. 2003 Nov;69(11):1031-5. doi: 10.1055/s-2003-45151.

DOI:10.1055/s-2003-45151

PMID:14735442

Abstract

Five new ent-kaurane diterpenoids, enanderianins K-O (1-5), and one new ent-abietane diterpenoid, enanderianin P (6), together with five known ent-kaurane diterpenoids, rabdocoetsin A (7), rabdocoetsin B (8), rabdocoetsin D (9), megathyrin A (10), megathyrin B (11) were isolated from the aerial parts of Isodon enanderianus. Their structures were determined by spectral means. Some diterpenoids were tested for their cytotoxicity against the human tumor K562 cells. Compounds 1, 2, 6, 8, 9 showed significant inhibitory activities against K562 cells with IC50 values ranging from 0.13 to 0.87 microg/mL.

摘要

从线纹香茶菜地上部分分离得到5个新的对映-贝壳杉烷二萜，线纹香茶菜素K - O（1 - 5），以及1个新的对映-枞烷二萜，线纹香茶菜素P（6），同时还得到5个已知的对映-贝壳杉烷二萜，香茶菜辛A（7）、香茶菜辛B（8）、香茶菜辛D（9）、大萼香茶菜素A（10）、大萼香茶菜素B（11）。通过波谱手段确定了它们的结构。测试了部分二萜对人肿瘤K562细胞的细胞毒性。化合物1、2、6、8、9对K562细胞显示出显著的抑制活性，IC50值范围为0.13至0.87μg/mL。