Jang Seon-Il, Jeong Seung-Il, Kim Kang-Ju, Kim Hyung-Jin, Yu Hyeon-Hee, Park Raekil, Kim Hyung-Min, You Yong-Ouk
Department of Oral Microbiology, School of Dentistry, Wonkwang University, Iksan, Chonbuk, South Korea.
Planta Med. 2003 Nov;69(11):1057-9. doi: 10.1055/s-2003-45157.
The inhibitory effects of tanshinone IIA, a diterpene isolated from Salvia miltiorrhiza root, on the production of nitric oxide (NO), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and the expression of inducible nitric oxide synthase (iNOS) were investigated in activated RAW 264.7 cells. This compound markedly inhibited the production of NO, IL-1beta and TNF-alpha, and suppressed the expression of iNOS in a dose-dependent manner. These results suggest that the traditional use of S. miltiorrhiza as an anti-inflammatory herbal medicine may be explained, in part, by the inhibition of NO, IL-1beta, IL-6 and TNF-alpha production, and expression of iNOS.
从丹参根部分离出的二萜类化合物丹参酮IIA对活化的RAW 264.7细胞中一氧化氮（NO）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的产生以及诱导型一氧化氮合酶（iNOS）的表达的抑制作用进行了研究。该化合物显著抑制NO、IL-1β和TNF-α的产生，并以剂量依赖性方式抑制iNOS的表达。这些结果表明，丹参作为一种抗炎草药的传统用途，部分原因可能是其对NO、IL-1β、IL-6和TNF-α产生以及iNOS表达的抑制作用。
