L-苏式-3,4-二羟基苯丝氨酸，一种去甲肾上腺素前体，在体内可抑制大鼠纹状体中的多巴胺释放及代谢。
L-threo-3,4-dihydroxyphenylserine, a noradrenaline precursor, inhibits dopamine release and metabolism in the rat striatum in vivo.
作者信息
Mizoguchi K, Tanaka M, Yokoo H, Yoshida M, Tsuda A
机构信息
Department of Pharmacology, Kurume University School of Medicine, Japan.
出版信息
Experientia. 1992 Dec 1;48(11-12):1133-4. doi: 10.1007/BF01948006.
The effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on dopamine (DA) release and metabolism in the striatum was studied in freely moving rats by intracerebral microdialysis techniques. The DA level as well as the levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly decreased 140 min after the administration of L-threo-DOPS (50 mg/kg intraperitoneally). The results suggest that L-threo-DOPS inhibits the release and metabolism of DA in the striatum.
采用脑内微透析技术，在自由活动的大鼠中研究了L-苏式-3,4-二羟基苯丝氨酸（L-苏式-DOPS）对纹状体中多巴胺（DA）释放及代谢的影响。腹腔注射L-苏式-DOPS（50mg/kg）140分钟后，DA水平以及3,4-二羟基苯乙酸和高香草酸水平均显著降低。结果表明，L-苏式-DOPS抑制纹状体中DA的释放及代谢。
Zotero 插件