Jones Kenneth
Armana Research, Inc., Halfmoon Bay, British Columbia, Canada.
J Altern Complement Med. 2003 Dec;9(6):877-96. doi: 10.1089/107555303771952235.
The objective of this review is to provide an overview of the pharmacologic evidence that may or may not support clinical and ethnomedical uses of the sap of sangre de drago (dragon's blood; Croton lechleri Müll. Arg.). Data sources used were BIOSIS, EMBASE, PubMed, TOXLIT, International Pharmaceutical Abstracts, manual searches, papers on file from peer-reviewed journals, textbooks available at Armana Research, Inc., and researchers in the field of South American botanical medicine.
The results of in vitro and in vivo studies largely support the majority of ethnomedical uses of sangre de drago including the treatment of diarrhea, wounds, tumors, stomach ulcers, herpes infection, the itching, pain and swelling of insect bites, and other conditions. Clinical studies of sangre de drago products have reported positive results in the treatment of traveler's and watery diarrhea and the symptoms of insect bites. Because the sap has shown low toxicity and preparations used in clinical studies were well tolerated, further clinical and pharmacologic studies are anticipated. Acknowledgment of the diversity in the chemical makeup of the sap from one geographic area to another and the recent characterization of alkaloid chemotypes of sangre de drago will require that materials developed for clinical use are standardized.
本综述的目的是概述可能支持或不支持龙血（克罗顿裂叶，Müll. Arg.）树液临床和民族医学用途的药理学证据。所使用的数据来源包括生物学文摘数据库（BIOSIS）、荷兰医学文摘数据库（EMBASE）、美国国立医学图书馆医学期刊数据库（PubMed）、毒理学文献数据库（TOXLIT）、国际药学文摘数据库、手工检索、同行评审期刊存档论文、阿曼纳研究公司提供的教科书以及南美植物医学领域的研究人员。
体外和体内研究结果在很大程度上支持了龙血在民族医学中的大多数用途，包括治疗腹泻、伤口、肿瘤、胃溃疡、疱疹感染、蚊虫叮咬引起的瘙痒、疼痛和肿胀以及其他病症。龙血产品的临床研究报告了在治疗旅行者腹泻和水样腹泻以及蚊虫叮咬症状方面的积极结果。由于树液显示出低毒性且临床研究中使用的制剂耐受性良好，预计将进行进一步的临床和药理学研究。鉴于不同地理区域树液化学成分的多样性以及最近对龙血生物碱化学型的表征，需要对临床使用的制剂进行标准化。
