Kemp G M, Hsiu J G, Andrews M C
Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia 23507.
Gynecol Oncol. 1992 Dec;47(3):395-7. doi: 10.1016/0090-8258(92)90147-b.
Prophylactic oophorectomy has been recommended in patients with a strongly positive family history for ovarian carcinoma. A patient with a strongly positive family history underwent a prophylactic oophorectomy and, 5 years later, developed a primary peritoneal papillary serous adenocarcinoma. A prophylactic oophorectomy does not afford complete protection in some patients with familial ovarian cancer syndrome. Any tissue derived from the coelomic epithelium may potentially undergo multifocal malignant transformation.
对于有卵巢癌家族史呈强阳性的患者，建议进行预防性卵巢切除术。一名有卵巢癌家族史呈强阳性的患者接受了预防性卵巢切除术，5年后发生了原发性腹膜乳头状浆液性腺癌。预防性卵巢切除术并不能为某些患有家族性卵巢癌综合征的患者提供完全的保护。任何来源于体腔上皮的组织都有可能发生多灶性恶性转化。
