Ma Peng-Fei, Zhuo Lin, Yuan Li-Ping, Qi Xiao-Hui
Department of Gastroenterology, Children's Hospital of Fudan University at Anhui (Anhui Provincial Children's Hospital), Hefei, Anhui, People's Republic of China.
Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
J Multidiscip Healthc. 2024 Feb 26;17:825-832. doi: 10.2147/JMDH.S454605. eCollection 2024.
(HP) infections affect approximately one-third of children worldwide. In China, the incidence of HP infection in children ranges from approximately 30% to 60%. In addition to damaging the gastrointestinal tract mucosa, HP infection in children can negatively affect their growth and development, hematology, respiratory and hepatobiliary system, skin, nutritional metabolism, and autoimmune system. However, the rate of HP eradication also fell considerably from the previous rate due to the presence of drug-resistant HP strains and the limited types of antibiotics that can be used in young patients. Vitamin D3 (VitD3) is a steroid hormone that can reduce inflammation in the stomach mucosa induced by HP and can alleviate and eradicate HP through a variety of pathways and mechanisms, including immune regulation and the stimulation of antimicrobial peptide (AMP) secretion and Ca influx, to reestablish lysosomal acidification; thus, these results provide new strategies and ideas for the eradication of drug-resistant HP strains.
幽门螺杆菌（HP）感染影响着全球约三分之一的儿童。在中国，儿童HP感染率约为30%至60%。儿童HP感染除了损害胃肠道黏膜外，还会对其生长发育、血液学、呼吸系统、肝胆系统、皮肤、营养代谢和免疫系统产生负面影响。然而，由于耐药HP菌株的存在以及可用于年轻患者的抗生素种类有限，HP根除率也较之前大幅下降。维生素D3（VitD3）是一种类固醇激素，它可以减轻HP诱导的胃黏膜炎症，并通过多种途径和机制缓解和根除HP，包括免疫调节、刺激抗菌肽（AMP）分泌和钙内流，以重建溶酶体酸化；因此，这些结果为根除耐药HP菌株提供了新的策略和思路。
