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父亲因素与出生体重的关系。

Relationship of paternal factors to birth weight.

作者信息

Nahum Gerard G, Stanislaw Harold

机构信息

Department of Obstetrics and Gynecology, Duke University Medical Center, 3241, Durham, NC 27710, USA.

出版信息

J Reprod Med. 2003 Dec;48(12):963-8.

Abstract

OBJECTIVE

To investigate the relationship between paternal characteristics and birth weight.

STUDY DESIGN

A total of 241 gravidas with uncomplicated, singleton, term pregnancies were studied. Maternal demographic and pregnancy-specific characteristics were used to calculate the expected birth weight for each fetus using a previously validated birth weight prediction equation. The additional independent predictive value of 4 paternal variables was assessed using multiple regression.

RESULTS

Before adjustment for other variables, paternal height and weight significantly correlated with birth weight, but paternal age and body mass index did not. After controlling for maternal and pregnancy-specific factors that are known to influence fetal weight, only paternal height was significant as a predictive variable. The proportion of variance in birth weight that could be independently explained by paternal height was 2%. A 10-g gain in fetal weight was associated with each centimeter of increase in paternal height (P < .02). Using the resulting combination equation that included paternal height as a variable, 31% of the variance in term birth weight could be explained, and birth weights could be accurately predicted to within +/- 8.3% (+/- 288 g). Fathers with heights 2 SD above and below the mean had the term birth weight of their offspring increased and diminished by 125 g, respectively.

CONCLUSION

Paternal height explains an independent portion of the variance in term birth weight among normal newborns of up to 250 g that cannot be explained by other maternal or pregnancy-specific factors. Paternal age, weight and body mass index do not independently influence birth weight.

摘要

目的

探讨父亲特征与出生体重之间的关系。

研究设计

共对241例单胎足月妊娠且无并发症的孕妇进行了研究。利用母亲的人口统计学和妊娠特异性特征,通过先前验证的出生体重预测方程计算每个胎儿的预期出生体重。使用多元回归评估4个父亲变量的额外独立预测价值。

结果

在对其他变量进行调整之前,父亲的身高和体重与出生体重显著相关,但父亲的年龄和体重指数则不然。在控制了已知会影响胎儿体重的母亲和妊娠特异性因素后,只有父亲的身高作为预测变量具有显著性。父亲身高能够独立解释的出生体重变异比例为2%。父亲身高每增加1厘米,胎儿体重增加10克(P <.02)。使用包含父亲身高作为变量的最终组合方程,可以解释足月出生体重变异的31%,并且出生体重能够被准确预测在±8.3%(±288克)范围内。父亲身高高于和低于平均值2个标准差的,其后代的足月出生体重分别增加和减少125克。

结论

在正常新生儿中,父亲身高可解释足月出生体重变异中独立的一部分,可达250克,这是其他母亲或妊娠特异性因素无法解释的。父亲的年龄、体重和体重指数不会独立影响出生体重。

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