Rabbani M A, Shah S M A, Ahmed A
Department of Medicine, The Aga Khan University Hospital, Karachi.
J Pak Med Assoc. 2003 Nov;53(11):539-41.
Systemic Lupus Erythematosus (SLE) is an autoimmune process in which cutaneous lesions occur in majority of patients. This study from Karachi, Pakistan was conducted to determine the pattern and prevalence of such lesions in SLE in Pakistani patients.
One hundred ninety eight patients with SLE fulfilling the clinical and laboratory criteria of the American Rheumatology Association were examined between 1986 and 2001 for the presence of cutaneous manifestations.
Skin changes noted were: noncicatricial diffuse alopecia (22%), malar rash (31%), mucosal lesions (20%), discoid eruptions (15%), photosensitivity (33%), vascular lesions (20%), pruritus (17%), and pigmentary changes (22%). Peripheral gangrene, chronic ulcers, Raynauds phenomenon, urticaria, chilblains, thrombophlebitis, palmar erythema, and erythema multiform were rare. Anti ANA and anti dsDNA were positive in 93% and 83% patients respectively.
A different clinical pattern was noted in our patients than reported previously.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，大多数患者会出现皮肤病变。本研究来自巴基斯坦卡拉奇，旨在确定巴基斯坦SLE患者此类病变的模式和患病率。
1986年至2001年间，对198例符合美国风湿病学会临床和实验室标准的SLE患者进行了皮肤表现检查。
观察到的皮肤变化有：非瘢痕性弥漫性脱发（22%）、蝶形红斑（31%）、黏膜病变（20%）、盘状红斑（15%）、光敏性（33%）、血管病变（20%）、瘙痒（17%）和色素沉着变化（22%）。周围坏疽、慢性溃疡、雷诺现象、荨麻疹、冻疮、血栓性静脉炎、掌部红斑和多形红斑较为罕见。抗核抗体（ANA）和抗双链DNA（dsDNA）分别在93%和83%的患者中呈阳性。
我们的患者中观察到的临床模式与之前报道的不同。
