Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
Nat Prod Res. 2020 Feb;34(4):494-502. doi: 10.1080/14786419.2018.1489392. Epub 2018 Nov 19.
A new xanthoquinodin B9 (), together with two known xanthoquinodins, xanthoquinodin A1 () and xanthoquinodin A3 (), three epipolythiodioxopiperazines, chetomin (), chaetocochin C () and dethio-tetra(methylthio)chetomin (), and four other compounds, chrysophanol (), emodin (), alatinone (), and ergosterol () were isolated from the endophytic fungus 7s-1, isolated from (Lour.) Mart. All isolated structures were established based on their spectroscopic data analyses. Compounds showed antibacterial activity against Gram positive bacteria with MICs ranging from 0.02 pM to 10.81 µM. Compounds also exhibited cytotoxicity against KB, MCF-7 and NCI-H187 cancer cell lines (IC 0.04-18.40 µM). However, they were cytotoxic towards a normal cell line ( cell) with IC values ranging from 0.04 to 3.86 µM.
从内生真菌 7s-1 中分离得到了（Lour.）Mart. 的叶子。所有分离得到的化合物结构均基于其光谱数据分析确定。化合物 对革兰氏阳性菌表现出抗菌活性，MIC 范围为 0.02-10.81μM。化合物 对 KB、MCF-7 和 NCI-H187 癌细胞系也表现出细胞毒性（IC 0.04-18.40μM）。然而，它们对正常细胞系（细胞）具有细胞毒性，IC 值范围为 0.04-3.86μM。
