贝尔格莱德儿童糖尿病研究：1型糖尿病的产前及社会关联因素

The Belgrade childhood diabetes study: prenatal and social associations for type 1 diabetes.

作者信息

Sipetić Sandra, Vlajinac Hristina, Kocev Nikola, Sají Silvija

机构信息

Institute of Epidemiology, School of Medicine, Belgrade University, Belgrade, Serbia and Montenegro.

出版信息

Paediatr Perinat Epidemiol. 2004 Jan;18(1):33-9. doi: 10.1111/j.1365-3016.2004.00533.x.

DOI:10.1111/j.1365-3016.2004.00533.x

PMID:14738545

Abstract

The aim of this study was to investigate whether prenatal and social factors are associated with the development of type 1 diabetes. A case-control study was conducted in Belgrade during the period 1994-97. A total of 105 children </= 16 years old with recently onset of diabetes and 210 control children, individually matched by age (+/- 1 year), sex and place of residence, were included in the study. In the analysis using multivariable logistic regression, the following factors were significantly related to type 1 diabetes: poor socio-economic status (Odds ratio = 4.18, 95% confidence interval [2.01, 8.72]); higher education of father (1.53, [1.16, 2.03]); complications during pregnancy (3.39, [1.64, 7.00]); ultrasound scan during pregnancy (0.40, [0.20, 0.79]); gestational age > 41 weeks (11.11, [1.80, 68.52]); mother's consumption of foods containing nitrosamines during pregnancy (3.14, [1.68, 5.87]); and consumption of alcohol by father (4.54, [2.34, 8.79]).

摘要

本研究的目的是调查产前因素和社会因素是否与1型糖尿病的发生有关。1994年至1997年期间在贝尔格莱德进行了一项病例对照研究。该研究纳入了105名16岁及以下近期发病的糖尿病儿童和210名对照儿童，这些对照儿童在年龄（±1岁）、性别和居住地点方面进行了个体匹配。在使用多变量逻辑回归的分析中，以下因素与1型糖尿病显著相关：社会经济地位低下（比值比=4.18，95%置信区间[2.01, 8.72]）；父亲受教育程度较高（1.53，[1.16, 2.03]）；孕期并发症（3.39，[1.64, 7.00]）；孕期超声检查（0.40，[0.20, 0.79]）；孕周>41周（11.11，[1.80, 68.52]）；母亲孕期食用含亚硝胺的食物（3.14，[1.68, 5.87]）；以及父亲饮酒（4.54，[2.34, 8.79]）。