Park Keun-Gyu, Park Kyong-Soo, Kim Mi-Jung, Kim Hye-Soon, Suh Young-Sung, Ahn Jong-Doek, Park Kwan-Kyu, Chang Young-Chae, Lee In-Kyu
Department of Internal Medicine, Keimyung University School of Medicine, Dongsan Medical Center, 194 Dongsan-Dong, Jung-Gu, Daegu 00-712, South Korea.
Diabetes Res Clin Pract. 2004 Feb;63(2):135-42. doi: 10.1016/j.diabres.2003.09.010.
The aim of this study was to investigate the relationship between adiponectin and leptin and body fat distribution. One hundred and ninety-seven women participated in this study. Subjects were grouped based on their visceral adipose tissue area (VAT). Body fat distribution was determined by computed tomography. The numbers in the subcutaneous fat dominant group (SFDG) and visceral fat dominant group (VFDG) were 79 and 118, respectively. The VFDG showed lower adiponectin levels than the SFDG (8.9+/-0.4 microg/ml versus 11.4+/-0.7 microg/ml, P=0.006), but leptin levels did not differ significantly between groups (18.8+/-1.1 ng/ml versus 17.7+/-1.8 ng/ml, P=0.111). Adiponectin levels were inversely correlated with fasting insulin, HOMA-IR, triglyceride, SBP and DBP, subcutaneous adipose tissue area (SAT) and VAT, and waist-to-hip ratio (WHR). Leptin levels were positively correlated with fasting glucose and insulin, HOMA-IR, triglyceride, SBP and DBP, VAT and SAT, and WHR (all values of P<0.05). VAT and HDL-cholesterol were independent variables of adiponectin concentrations (R(2)=0.207, P<0.0001), and SAT, fasting insulin, and HOMA-IR were independent variables of leptin concentrations (R(2)=0.498, P<0.0001) In conclusion, adiponectin and leptin concentrations, although associated with metabolic parameters, were more strongly influenced by VAT in the case of adiponectin, and by SAT in the case of leptin.
本研究旨在探讨脂联素、瘦素与体脂分布之间的关系。197名女性参与了本研究。根据内脏脂肪组织面积（VAT）对受试者进行分组。通过计算机断层扫描确定体脂分布。皮下脂肪占主导组（SFDG）和内脏脂肪占主导组（VFDG）的人数分别为79人和118人。VFDG的脂联素水平低于SFDG（8.9±0.4微克/毫升对11.4±0.7微克/毫升，P = 0.006），但两组间瘦素水平无显著差异（18.8±1.1纳克/毫升对17.7±1.8纳克/毫升，P = 0.111）。脂联素水平与空腹胰岛素、HOMA-IR、甘油三酯、收缩压和舒张压、皮下脂肪组织面积（SAT）、VAT以及腰臀比（WHR）呈负相关。瘦素水平与空腹血糖和胰岛素、HOMA-IR、甘油三酯、收缩压和舒张压、VAT、SAT以及WHR呈正相关（所有P值<0.05）。VAT和高密度脂蛋白胆固醇是脂联素浓度的独立变量（R² = 0.207，P<0.0001），SAT、空腹胰岛素和HOMA-IR是瘦素浓度的独立变量（R² = 0.498，P<0.0001）。总之，脂联素和瘦素浓度虽然与代谢参数相关，但脂联素方面受VAT影响更大，瘦素方面受SAT影响更大。
