Zheng Aiping, Zhang Lei, Yang Jiaqing, Yin Xiaomeng, Zhang Tao, Wu Xin, Ma Xuelei
Division of Biotherapy, Cancer Center, West China Hospital, Cancer Center, Sichuan University, Chengdu, China.
Head and Neck Oncology Ward, Cancer Center, West China Hospital, Cancer Center, Sichuan University, Chengdu, China.
Front Pharmacol. 2022 Oct 12;13:1034129. doi: 10.3389/fphar.2022.1034129. eCollection 2022.
Metastasis is responsible for 90% of deaths in cancer patients. Most patients diagnosed with metastatic cancer will die within 5 years. PA is good for health and has become an emerging adjuvant therapy for cancer survivors. Regular moderate exercise substantially lowers the incidence and recurrence of several cancers, alleviates cancer-related adverse events, enhances the efficacy of anti-cancer treatments, and improves the quality of life of cancer patients. Revealing the mechanisms of PA inhibiting tumor metastasis could upgrade our understanding of cancer biology and help researchers explore new therapeutic strategies to improve survival in cancer patients. However, it remains poorly understood how physical activity prevents metastasis by modulating tumor behavior. The immune system is involved in each step of tumor metastasis. From invasion to colonization, immune cells interact with tumor cells to secret cytokines and proteases to remodel the tumor microenvironment. Substantial studies demonstrated the ability of physical activity to induce antitumor effects of immune cells. This provides the possibility that physical activity can modulate immune cells behavior to attenuate tumor metastasis. The purpose of this review is to discuss and summarize the critical link between immune function and exercise in metastasis prevention.
转移是导致癌症患者90%死亡的原因。大多数被诊断为转移性癌症的患者将在5年内死亡。体育活动对健康有益，已成为癌症幸存者的一种新兴辅助疗法。定期适度运动可大幅降低几种癌症的发病率和复发率，减轻癌症相关不良事件，提高抗癌治疗的疗效，并改善癌症患者的生活质量。揭示体育活动抑制肿瘤转移的机制可以提升我们对癌症生物学的理解，并帮助研究人员探索新的治疗策略以提高癌症患者的生存率。然而，体育活动如何通过调节肿瘤行为来预防转移仍知之甚少。免疫系统参与肿瘤转移的每一步。从侵袭到定植，免疫细胞与肿瘤细胞相互作用，分泌细胞因子和蛋白酶以重塑肿瘤微环境。大量研究证明了体育活动诱导免疫细胞产生抗肿瘤作用的能力。这提供了体育活动可以调节免疫细胞行为以减轻肿瘤转移的可能性。本综述的目的是讨论和总结免疫功能与运动在预防转移中的关键联系。
