Moody D Branch, Young David C, Cheng Tan-Yun, Rosat Jean-Pierre, Roura-Mir Carme, O'Connor Peter B, Zajonc Dirk M, Walz Andrew, Miller Marvin J, Levery Steven B, Wilson Ian A, Costello Catherine E, Brenner Michael B
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA.
Science. 2004 Jan 23;303(5657):527-31. doi: 10.1126/science.1089353.
Unlike major histocompatibility proteins, which bind peptides, CD1 proteins display lipid antigens to T cells. Here, we report that CD1a presents a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. T cell activation was mediated by the alphabeta T cell receptors and was specific for structure of the acyl and peptidic components of these antigens. These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity.
与结合肽的主要组织相容性蛋白不同，CD1蛋白向T细胞呈递脂质抗原。在此，我们报告CD1a呈递了一类来自结核分枝杆菌的此前未知的脂肽，因其与分枝杆菌铁载体的结构关系而被命名为双脱氢分枝杆菌素。T细胞活化由αβ T细胞受体介导，且对这些抗原的酰基和肽组分的结构具有特异性。这些研究确定了一种细胞内病原体检测方式，并将脂肽鉴定为T细胞的一类生化抗原，这类抗原与传统肽一样，具有显著结构多样性的潜力。
