优里他汀A和B，新型脯氨酰内肽酶抑制剂。I. 分类、生产、分离及生物活性

Eurystatins A and B, new prolyl endopeptidase inhibitors. I. Taxonomy, production, isolation and biological activities.

作者信息

Toda S, Obi Y, Numata K, Hamagishi Y, Tomita K, Komiyama N, Kotake C, Furumai T, Oki T

机构信息

Bristol-Myers Squibb Research Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1992 Oct;45(10):1573-9. doi: 10.7164/antibiotics.45.1573.

DOI:10.7164/antibiotics.45.1573

PMID:1473984

Abstract

Eurystatins A and B, were isolated from the cultured broth of Streptomyces eurythermus R353-21. They showed specific and potent inhibitory activity against prolyl endopeptidase and did not show antimicrobial activity. No lethal toxicity was observed for the two compounds after ip administration in mice at 200 mg/kg.

摘要

优里他汀A和B是从嗜温链霉菌R353 - 21的培养液中分离得到的。它们对脯氨酰内肽酶表现出特异性和强效抑制活性，且无抗菌活性。给小鼠腹腔注射200mg/kg的这两种化合物后，未观察到致死毒性。