一种新的蒽环类抗生素，烬灰红菌素R。分类学、结构解析及生物活性。
A new anthracycline antibiotic, cinerubin R. Taxonomy, structural elucidation and biological activity.
作者信息
Nakata M, Saito M, Inouye Y, Nakamura S, Hayakawa Y, Seto H
机构信息
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
出版信息
J Antibiot (Tokyo). 1992 Oct;45(10):1599-608. doi: 10.7164/antibiotics.45.1599.
A novel anthracycline antibiotic, cinerubin R, was isolated from the fermentation broth of Streptomyces eurythermus strain H1715MY2. The structure of cinerubin R was elucidated to be 4"-aculosyl-4'-rhodinosyl-7-rhodosaminyl-epsilon-py rromycinone. Cinerubin R was active against Gram-positive bacteria and inhibited the growth of divergent multi-drug-resistant cells to the same extent as their parental cells.
一种新型蒽环类抗生素——烬灰红菌素R，是从嗜温链霉菌H1715MY2菌株的发酵液中分离得到的。烬灰红菌素R的结构被确认为4"-阿库糖基-4'-鼠李糖基-7-鼠李糖胺基-ε-吡咯霉素酮。烬灰红菌素R对革兰氏阳性菌有活性，并且对多种耐药细胞的抑制生长程度与亲本细胞相同。
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