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[对比剂在高场强磁共振成像(3T)中的应用]

[Use of contrast agent in high-field MRI (3 T)].

作者信息

Trattnig S, Ba-Ssalamah A, Nöbauer-Huhmann I M, Barth M, Pinker K, Mlynarik V

机构信息

Universitätsklinik für Radiodiagnostik, Allgemeines Krankenhaus Wien, Vienna, Austria.

出版信息

Radiologe. 2004 Jan;44(1):56-64. doi: 10.1007/s00117-003-0964-x.

Abstract

The basic diagnostic efficacy of MR contrast medium in the evaluation of primary brain tumors and its clinical usefulness in the detection of brain metastases with single and cumulative triple-dose was compared using a high-field 3 T MR unit and a 1.5 T MR unit. Additionally, the effect of contrast agent on high-resolution MR venography based on the BOLD effect was evaluated at both field strengths. Tumor-brain contrast after gadodiamide administration, as assessed by means of statistical evaluation of MP-RAGE scans and T1-SE images, was significantly higher at 3 T than at 1.5 T. The subjective assessment of cumulative triple-dose 3 T images obtained the best results in the detection of brain metastases, followed by 1.5 T cumulative triple-dose enhanced images. Due to higher spatial resolution, contrast-enhanced MR venography at 3 T showed more details in and around tumors than at 1.5 T, additionally enhanced by stronger susceptibility weighting and higher signal-to-noise ratio at 3 T. In summary, administration of gadolinium-based contrast agent produces higher contrast between tumor and normal brain at 3 T than at 1.5 T, helps to detect more cerebral metastases at 3 T than at 1.5 T in single and cumulative triple dose, and improves MR venography at 3 T with increase in spatial resolution within the same measurement time, thus providing more detailed information.

摘要

使用高场3T磁共振成像(MR)设备和1.5T MR设备,比较了MR造影剂在评估原发性脑肿瘤中的基本诊断效能及其在单次和累积三倍剂量检测脑转移瘤中的临床应用价值。此外,在两种场强下评估了造影剂对基于血氧水平依赖(BOLD)效应的高分辨率MR静脉血管造影的影响。通过对MP-RAGE扫描和T1-SE图像进行统计学评估,钆双胺给药后的肿瘤-脑对比度在3T时显著高于1.5T。在检测脑转移瘤方面,对3T累积三倍剂量图像的主观评估获得了最佳结果,其次是1.5T累积三倍剂量增强图像。由于空间分辨率更高, 3T的对比增强MR静脉血管造影比1.5T能更清晰地显示肿瘤内部及周围的细节,此外,3T时更强的磁化率加权和更高的信噪比也增强了这种效果。总之,钆基造影剂的使用在3T时比1.5T能在肿瘤与正常脑之间产生更高的对比度,在单次和累积三倍剂量下,3T比1.5T能检测到更多的脑转移瘤,并且在相同测量时间内提高了3T的MR静脉血管造影的空间分辨率,从而提供更详细的信息。

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