Ateş Nurcan Aras, Tursen Umit, Tamer Lülüfer, Kanik Arzu, Derici Ebru, Ercan Bahadir, Atik Ugur
Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, 33079 Yenişehir Mersin, Turkey.
Arch Dermatol Res. 2004 Mar;295(10):429-33. doi: 10.1007/s00403-003-0446-z. Epub 2004 Jan 22.
Glutathione S-transferase (GST) enzymes play an important role in drug metabolism. GST is a multigene family of enzymes involved in the detoxification and in a few instances activation of a wide variety of chemicals. Detoxification features make it plausible to search for GST polymorphism in patients with drug eruption. The GSTM (mu), GSTT (theta) and GSTP (pi) have been shown to be polymorphically distributed. The GSTT1, GSTM1 and GSTP1 gene polymorphism were detected using real-time PCR. GSTM1 and GSTT1 null genotypes were found to be associated with an increased risk of drug eruption (OR 2.27, 95% CI 1.20-5.21; OR 2.48, 95% CI 1.12-6.39, respectively). No relationship was observed between the null combination of the GSTM1 and GSTT1 genotype polymorphisms and drug eruption risk (OR 2.65, 95% CI 0.62-11.25). Our results show that GSTP1 polymorphism is not a significant contributor to drug eruption risk. The GSTM1 and GSTT1 gene polymorphisms seem to be associated with the development of drug eruption. Further studies may shed additional light on the role of GSTM1, GSTT1 and GSTP1 in drug eruption.
谷胱甘肽S - 转移酶（GST）在药物代谢中起重要作用。GST是一个多基因家族的酶，参与多种化学物质的解毒过程，在少数情况下也参与其活化。解毒特性使得在药疹患者中寻找GST多态性成为可能。已证明GSTM（μ）、GSTT（θ）和GSTP（π）呈多态性分布。使用实时PCR检测GSTT1、GSTM1和GSTP1基因多态性。发现GSTM1和GSTT1缺失基因型与药疹风险增加相关（分别为OR 2.27，95% CI 1.20 - 5.21；OR 2.48，95% CI 1.12 - 6.39）。未观察到GSTM1和GSTT1基因型多态性的缺失组合与药疹风险之间的关系（OR 2.65，95% CI 0.62 - 11.25）。我们的结果表明，GSTP1多态性不是药疹风险的重要因素。GSTM1和GSTT1基因多态性似乎与药疹的发生有关。进一步的研究可能会更清楚地揭示GSTM1、GSTT1和GSTP1在药疹中的作用。
