Yomota Chikako
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2003(121):30-3.
Hyaluronate (HA), a glycosaminoglycan polysaccharide, has been used for osteoarthritis, periartritis of the shoulder and rheumatoid arthritis by intraarticular administration, and in ophthalmic surgery such as anterior segment surgery, and eye lotion. In this study, the molecular weight (Mw) of HA preparations were estimated by size-exclusion chromatography (SEC) system consisted of a refractometer (RI) and a multi-angle laser light scattering (MALS). From the results, it has been clarified that a successful characterization of HA samples with Mw up to 2 - 3 x 10(6) g/mol was possible by multidetector system.
透明质酸盐（HA）是一种糖胺聚糖多糖，已通过关节内给药用于骨关节炎、肩周炎和类风湿性关节炎，以及用于眼前段手术等眼科手术和洗眼液中。在本研究中，通过由示差折光仪（RI）和多角度激光光散射仪（MALS）组成的尺寸排阻色谱（SEC）系统来估计HA制剂的分子量（Mw）。从结果来看，已明确通过多检测器系统能够成功表征Mw高达2 - 3×10⁶ g/mol的HA样品。
