James G D, Sievert L Leidy, Flanagan E
Institute for Primary and Preventative Health Care, Binghamton University, SUNY, NY 13902-6000, USA.
Ann Hum Biol. 2004 Jan-Feb;31(1):49-58. doi: 10.1080/03014460310001636561.
The purpose of this study was to evaluate whether ambulatory blood pressure and heart rate varied with hot flash experience among women of menopausal age.
A total of 1149 ambulatory blood pressure and heart rate measurements from 20 women aged 44-55 were examined. Women were categorized by hot flash experience as (1) having had hot flashes during the study period (Symptomatic during Study; n = 5; 302 measurements), (2) having a past history of hot flashes, but no hot flashes during the study period (Historically Symptomatic; n = 7; 385 measurements), and (3) never having had a hot flash (Asymptomatic; n = 8; 462 measurements). Using repeated measures, nested ANOVA models that also adjusted for posture, the variation in blood pressure and heart rate associated with hot flash experience over the whole day and by location of measurement (microenvironment) was evaluated.
The results show that, overall, systolic pressure did not differ among the hot flash experience groups although the Symptomatic during Study group had higher pressures at work than the other two groups (p<0.01), and tended to have higher pressures during sleep (p<0.08). The sleep diastolic pressure of the Asymptomatic group was significantly lower than that of the women who had hot flashes on the study day (p<0.01), but women who had a past history of hot flashes had slightly lower diastolic pressure (p<0.01) than those in the other two groups overall. Heart rates of the Asymptomatic group, however, were significantly lower (4-6 b.p.m.; p<0.001) in each microenvironment and over the whole day than both groups who had hot flash experience.
These data suggest first that there may be a relationship between the experience of hot flashes and accelerated heart rate, and second that women who do not experience hot flashes may have lower sleep blood pressures than women who do.
本研究旨在评估绝经年龄女性的动态血压和心率是否随潮热经历而变化。
对20名年龄在44 - 55岁女性的1149次动态血压和心率测量数据进行了检查。根据潮热经历，将女性分为三类：（1）在研究期间有潮热（研究期间有症状；n = 5；302次测量），（2）有潮热病史，但在研究期间无潮热（既往有症状；n = 7；385次测量），以及（3）从未有过潮热（无症状；n = 8；462次测量）。采用重复测量，使用嵌套方差分析模型并对姿势进行校正，评估了与潮热经历相关的全天及各测量位置（微环境）的血压和心率变化。
结果显示，总体而言，潮热经历组之间收缩压无差异，尽管研究期间有症状组在工作时的血压高于其他两组（p < 0.01），且在睡眠期间血压也有升高趋势（p < 0.08）。无症状组的睡眠舒张压显著低于研究当天有潮热的女性（p < 0.01），但总体而言，有潮热病史的女性的舒张压略低于其他两组（p < 0.01）。然而，无症状组在每个微环境及全天的心率均显著低于有潮热经历的两组（低4 - 6次/分钟；p < 0.001）。
这些数据表明，首先潮热经历与心率加快之间可能存在关联，其次未经历潮热的女性睡眠血压可能低于有潮热经历的女性。
