基因笔记：正常人体组织中的全基因组表达谱
GeneNote: whole genome expression profiles in normal human tissues.
作者信息
Shmueli Orit, Horn-Saban Shirley, Chalifa-Caspi Vered, Shmoish Michael, Ophir Ron, Benjamin-Rodrig Hila, Safran Marilyn, Domany Eytan, Lancet Doron
机构信息
Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel.
出版信息
C R Biol. 2003 Oct-Nov;326(10-11):1067-72. doi: 10.1016/j.crvi.2003.09.012.
A novel data set, GeneNote (Gene Normal Tissue Expression), was produced to portray complete gene expression profiles in healthy human tissues using the Affymetrix GeneChip HG-U95 set, which includes 62 839 probe-sets. The hybridization intensities of two replicates were processed and analyzed to yield the complete transcriptome for twelve human tissues. Abundant novel information on tissue specificity provides a baseline for past and future expression studies related to diseases. The data is posted in GeneNote (http://genecards.weizmann.ac.il/genenote/), a widely used compendium of human genes (http://bioinfo.weizmann.ac.il/genecards).
利用包含62839个探针集的Affymetrix GeneChip HG-U95芯片组，构建了一个名为GeneNote（基因正常组织表达）的新型数据集，用于描绘健康人体组织中的完整基因表达谱。对两个重复样本的杂交强度进行处理和分析，以获得12种人体组织的完整转录组。大量关于组织特异性的新信息为过去和未来与疾病相关的表达研究提供了基线。该数据发布在GeneNote（http://genecards.weizmann.ac.il/genenote/）上，GeneNote是一个广泛使用的人类基因汇编（http://bioinfo.weizmann.ac.il/genecards）。
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