戊聚糖多硫酸盐在预防草酸钙结石方面有作用吗？

Is there a role for pentosan polysulfate in the prevention of calcium oxalate stones?

作者信息

Jones Marklyn, Monga Manoj

机构信息

Department of Urologic Surgery, University of Minnesota, 1420 Delaware Street SE, Minneapolis, MN 55455, USA.

出版信息

J Endourol. 2003 Dec;17(10):855-8. doi: 10.1089/089277903772036136.

DOI:10.1089/089277903772036136

PMID:14744348

Abstract

The clinical role for pentosan polysulfate (PPS) in the prevention of calcium oxalate urolithiasis is not known. Crystallization and aggregation are important steps in calcium oxalate stone formation, and PPS has been shown to inhibit these steps, both in vitro and in vivo. In addition, PPS has a role in repairing injured urothelium and inhibiting adhesion to epithelial defects. A randomized double-blind placebo-controlled study appears warranted to assess the utility of PPS in the prevention of recurrent calcium oxalate stones.

摘要

戊聚糖多硫酸盐（PPS）在预防草酸钙尿路结石方面的临床作用尚不清楚。结晶和聚集是草酸钙结石形成的重要步骤，并且已表明PPS在体外和体内均能抑制这些步骤。此外，PPS在修复受损的尿路上皮和抑制对上皮缺损的黏附方面具有作用。开展一项随机双盲安慰剂对照研究似乎有必要，以评估PPS在预防复发性草酸钙结石方面的效用。