Martin X, Werness P G, Bergert J H, Smith L H
J Urol. 1984 Oct;132(4):786-8. doi: 10.1016/s0022-5347(17)49873-9.
Pentosan polysulfate was studied as a calcium oxalate crystal growth inhibitor. The inhibition from pentosan polysulfate at concentrations ranging from 3.5 to 110 mg./l. was measured in simple inorganic calcium oxalate solutions at pH 5, 6 and 7. Pentosan polysulfate also was mixed with urine at concentrations from 10 to 350 mg./l. and inhibition determined. Measurement of calcium oxalate crystal growth inhibition was performed in a seeded crystal growth system. One inhibitory unit (concentration of pentosan polysulfate necessary to give a 50 per cent reduction in the rate of crystal growth) was 5.7 +/- 2 mg./l. at pH 5, 7.2 +/- 1.1 mg./l. at pH 6 and 6.0 +/- 2.1 mg./l. at pH 7. Urine-pentosan polysulfate mixtures showed more inhibitory activity than the predicted inhibition present. Addition of pentosan polysulfate to urine at a concentration of 10 mg./l. increased the inhibitory activity from 45 +/- 3 to 59 +/- 3 IU/l. Pentosan polysulfate is a potent calcium oxalate crystal growth inhibitor in urine at physiologic pH levels. If the urinary concentration of pentosan polysulfate after oral administration reaches 10 mg./l., the increase in inhibitory activity in urine that may occur might be important in the treatment of patients who form calcium oxalate calculi within the urinary tract.
对戊聚糖多硫酸盐作为草酸钙晶体生长抑制剂进行了研究。在pH值为5、6和7的简单无机草酸钙溶液中，测定了浓度范围为3.5至110毫克/升的戊聚糖多硫酸盐的抑制作用。戊聚糖多硫酸盐还以10至350毫克/升的浓度与尿液混合，并测定其抑制作用。在接种晶体生长系统中进行草酸钙晶体生长抑制的测量。一个抑制单位（使晶体生长速率降低50%所需的戊聚糖多硫酸盐浓度）在pH值为5时为5.7±2毫克/升，在pH值为6时为7.2±1.1毫克/升，在pH值为7时为6.0±2.1毫克/升。尿液-戊聚糖多硫酸盐混合物显示出比预测的抑制作用更强的抑制活性。以10毫克/升的浓度向尿液中添加戊聚糖多硫酸盐，可使抑制活性从45±3国际单位/升增加到59±3国际单位/升。在生理pH水平下，戊聚糖多硫酸盐是尿液中一种有效的草酸钙晶体生长抑制剂。如果口服后尿液中戊聚糖多硫酸盐的浓度达到10毫克/升，尿液中可能出现的抑制活性增加对于治疗尿路中形成草酸钙结石的患者可能具有重要意义。
