Kadonaga James T
Section of Molecular Biology, 0347, University of California, San Diego, La Jolla, CA 92093, USA.
Cell. 2004 Jan 23;116(2):247-57. doi: 10.1016/s0092-8674(03)01078-x.
In eukaryotes, transcription of the diverse array of tens of thousands of protein-coding genes is carried out by RNA polymerase II. The control of this process is predominantly mediated by a network of thousands of sequence-specific DNA binding transcription factors that interpret the genetic regulatory information, such as in transcriptional enhancers and promoters, and transmit the appropriate response to the RNA polymerase II transcriptional machinery. This review will describe some early advances in the discovery and characterization of the sequence-specific DNA binding transcription factors as well as some of the properties of these regulatory proteins.
在真核生物中，数以万计的蛋白质编码基因的转录由RNA聚合酶II进行。这一过程的控制主要由数千种序列特异性DNA结合转录因子组成的网络介导，这些转录因子解读遗传调控信息，如在转录增强子和启动子中，并将适当的反应传递给RNA聚合酶II转录机制。本综述将描述序列特异性DNA结合转录因子发现和表征方面的一些早期进展以及这些调控蛋白的一些特性。
