Hu Shasa, Ma Fangchao, Collado-Mesa Fernando, Kirsner Robert S
Department of Dermatology and Cutaneous Surgery, Sylvester Cancer Center, University of Miami School of Medicine, Miami, Florida, USA.
Cancer Epidemiol Biomarkers Prev. 2004 Jan;13(1):59-64. doi: 10.1158/1055-9965.epi-03-0187.
Non-Hodgkin's lymphoma (NHL) is one of the most common cancers among American Hispanics. Several studies suggest that solar UV radiation (UVR) may be an environmental risk contributing to the rise of NHL over the past decades. These studies focused primarily on light-skinned Caucasian populations; it is unknown what role UVR plays in NHL for Hispanics. We described the incidence of NHL in Hispanics from selected states in the United States between 1989 and 2000. To evaluate the role of UVR, we correlated cancer rates with the UV index and latitude of residency. Variations in NHL incidence rates with estimated amount of UVR among whites and blacks from the selected states were also analyzed. We found that NHL occurred less frequently in Hispanics than in whites. Hispanic men had higher incidence of NHL than Hispanic women. Incidence rates of NHL in Hispanics were inversely associated with estimated amount of UVR as an increase in NHL was observed with decreasing UV index (r = -0.7 in men; r = -0.41 in women) or increasing latitude of residency (r = 0.59 in men; r = 0.48 in women). This trend, although it did not reach statistical significance, was also observed in whites and blacks. Our findings do not support previous reports of a positive association between solar radiation and NHL. The inverse relationship between UVR and incidence of NHL is unexplained but presents the need for generation of hypotheses regarding the epidemiology of causal factors for NHL in the United States. Additional studies should be conducted to clarify whether sunlight exposure contributes to the development of NHL.
非霍奇金淋巴瘤（NHL）是美国西班牙裔中最常见的癌症之一。多项研究表明，太阳紫外线辐射（UVR）可能是过去几十年来导致NHL发病率上升的一种环境风险因素。这些研究主要集中在浅肤色的白人群体；UVR在西班牙裔NHL发病中所起的作用尚不清楚。我们描述了1989年至2000年间美国部分州西班牙裔人群中NHL的发病率。为了评估UVR的作用，我们将癌症发病率与紫外线指数和居住纬度进行了关联分析。我们还分析了所选州白人和黑人中NHL发病率随UVR估计量的变化情况。我们发现，西班牙裔人群中NHL的发病率低于白人。西班牙裔男性的NHL发病率高于女性。西班牙裔人群中NHL的发病率与UVR估计量呈负相关，即随着紫外线指数降低（男性r = -0.7；女性r = -0.41）或居住纬度增加（男性r = 0.59；女性r = 0.48），NHL发病率上升。在白人和黑人中也观察到了这种趋势，尽管未达到统计学显著性。我们的研究结果不支持先前关于太阳辐射与NHL呈正相关的报道。UVR与NHL发病率之间的负相关关系尚无合理解释，但这表明有必要针对美国NHL病因因素的流行病学提出假设。应开展更多研究以阐明阳光照射是否会促进NHL的发生。
