Buinewicz Brian, Rosen Brent
Abington Memorial Hospital, PA, USA.
Ann Plast Surg. 2004 Feb;52(2):188-94. doi: 10.1097/01.sap.0000100895.41198.27.
AlloDerm is an intact human tissue matrix with the critical biochemical and structural components of the dermal extracellular scaffold that enable it to recellularize and revascularize. Its biologic nature provides AlloDerm with an improved capacity to reintegrate with surrounding tissues and less inclination toward infection, erosion, extrusion, and rejection compared with synthetic tissue replacement materials. This retrospective review describes the experience with AlloDerm for incisional hernia and transverse rectus abdominis musculocutaneous flap reconstructions at a plastic surgery practice that handles complex, nonprimary repairs. AlloDerm was observed to provide exceptional safety and tolerability, and to become reintegrated and vascularized with surrounding tissue for tolerable and persistent tissue replacement.
异体真皮是一种完整的人体组织基质，具有真皮细胞外支架的关键生化和结构成分，使其能够重新细胞化和血管化。与合成组织替代材料相比，其生物学特性使异体真皮具有更强的与周围组织重新整合的能力，且感染、侵蚀、挤出和排斥的倾向更小。本回顾性研究描述了在一家进行复杂非一期修复的整形外科诊所使用异体真皮进行切口疝和腹直肌横形肌皮瓣重建的经验。观察到异体真皮具有出色的安全性和耐受性，并能与周围组织重新整合并血管化，以实现可耐受且持久的组织替代。
