Taylor Terrie E, Fu Wenjiang J, Carr Richard A, Whitten Richard O, Mueller Jeffrey S, Fosiko Nedson G, Lewallen Susan, Liomba N George, Molyneux Malcolm E
Department of Internal Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan 48824, USA.
Nat Med. 2004 Feb;10(2):143-5. doi: 10.1038/nm986. Epub 2004 Jan 25.
To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.
为研究致死性脑型疟疾的发病机制，我们对31例临床诊断为此病的儿童进行了尸检。我们发现23%的儿童实际上死于其他原因。其余患者的寄生虫隐匿于脑毛细血管中，其中75%的患者伴有血管内和血管周围的其他病变。视网膜病变是区分疟疾性昏迷和非疟疾性昏迷的唯一临床体征。这些数据对疟疾患者的治疗、临床试验设计及评估疟疾特异性疾病关联具有重要意义。
