Grützmann Robert, Saeger Hans Detlev, Lüttges Jutta, Schackert Hans Konrad, Kalthoff Holger, Klöppel Günter, Pilarsky Christian
Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, Dresden, Germany.
Int J Colorectal Dis. 2004 Sep;19(5):401-13. doi: 10.1007/s00384-003-0563-3. Epub 2004 Jan 24.
Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells.
As several studies using microarrays have already been published, this review attempts to compare published data and crossvalidate the results. In addition, the applied techniques are discussed.
胰腺导管腺癌的预后极差。为改善预后，需要确定用于早期诊断以及辅助和/或新辅助治疗的新型分子标志物和靶点。为实现这一目标而开发的关键技术之一是DNA微阵列分析，其用于识别胰腺癌细胞中分子功能失调的机制。
由于已经发表了几项使用微阵列的研究，本综述试图比较已发表的数据并对结果进行交叉验证。此外，还讨论了所应用的技术。
