Tubbs R Shane, Wellons John C, Oakes W Jerry
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Childs Nerv Syst. 2005 Feb;21(2):161-4. doi: 10.1007/s00381-003-0895-x. Epub 2004 Jan 23.
Situs inversus is a rare condition of visceral transposition in which the spinal axis is rarely affected.
The authors report a patient with situs inversus totalis and Type II split cord malformation. The patient had no symptoms and presented with scoliosis.
Recent compelling evidence from animal models and human case reports has lead to hypotheses that defects of the midline and laterality defects (e.g., situs inversus) are etiologically related. Confirmation from additional case reports of situs inversus and split cord malformation could prove useful in determining a genetic locus for split cord malformations or implicating various chemical agents that are known to produce situs inversus as potential causative factors in the production of split cord malformations.
内脏反位是一种罕见的内脏转位情况，其中脊柱轴很少受到影响。
作者报告了一例全内脏反位合并II型脊髓纵裂畸形的患者。该患者无症状，表现为脊柱侧弯。
最近来自动物模型和人类病例报告的有力证据引发了一些假设，即中线缺陷和左右侧缺陷（如内脏反位）在病因上相关。更多内脏反位和脊髓纵裂畸形病例报告的证实，可能有助于确定脊髓纵裂畸形的基因位点，或表明各种已知会导致内脏反位的化学物质是脊髓纵裂畸形产生的潜在致病因素。
