转化生长因子-β 受体超家族

The transforming growth factor-beta superfamily of receptors.

作者信息

de Caestecker Mark

机构信息

Division of Nephrology, S-3223 Medical Center North, 1161 21st Street S, Nashville, TN 37232-2372, USA.

出版信息

Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11. doi: 10.1016/j.cytogfr.2003.10.004.

DOI:10.1016/j.cytogfr.2003.10.004

PMID:14746809

Abstract

The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type I, and type II receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The purpose of this review is to describe the biochemical properties of these receptors, focusing specifically on the mechanisms regulating receptor/ligand interactions and activation in mammalian cells.

摘要

转化生长因子-β（TGF-β）受体超家族由两组跨膜丝氨酸-苏氨酸激酶受体组成，即所谓的I型和II型受体，它们在被TGF-β配体超家族的成员结合后被激活。这些事件决定了不同的下游反应，这些反应通过控制不同细胞类型中配体、其受体和下游底物的可及性及激活而受到差异调节。本综述的目的是描述这些受体的生化特性，特别关注调节哺乳动物细胞中受体/配体相互作用及激活的机制。