Das Samyabrata, Thakur Amit, Datta Anupam, Sahoo Ayaskant, Bandyopadhyay Sukanta, Sah Ashok K
Orthopaedic Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Department of Orthopaedics and Traumatology, All India Institute of Medical Science Jammu, Jammu, IND.
Cureus. 2025 Feb 28;17(2):e79860. doi: 10.7759/cureus.79860. eCollection 2025 Feb.
Orthopedics is one field that greatly benefits from the new ideas provided by regenerative medicine. This review pulls together the most recent publications involving stem cell therapy, platelet-rich plasma, growth factor, gene therapy, tissue engineering, stem cell-derived extracellular vesicles, and other regenerative technologies in the context of bone, cartilage, tendon, and ligament healing. Recent studies show that these new therapies can alter cell development, division, and production of fiber and ground substance to remodel tissues. Nevertheless, the clinical application has several issues such as the standardization of cell procurement and preparation, the control of cytokine/gene delivery, the revascularization of tissues, and the requirements of large samples, positively controlled clinical trials. More research must be conducted to overcome such barriers and make practicing more applicable in real life.
骨科是从再生医学提供的新思想中受益匪浅的一个领域。本综述汇集了涉及干细胞疗法、富血小板血浆、生长因子、基因疗法、组织工程、干细胞衍生的细胞外囊泡以及其他再生技术在骨、软骨、肌腱和韧带愈合方面的最新出版物。最近的研究表明，这些新疗法可以改变细胞发育、分裂以及纤维和基质的产生，从而重塑组织。然而，临床应用存在几个问题，如细胞采集和制备的标准化、细胞因子/基因递送的控制、组织的血管再生以及大样本、阳性对照临床试验的要求。必须进行更多的研究来克服这些障碍，使实践在现实生活中更具适用性。
