固定膜的动力学及其在红细胞表面蛋白质扩散中的应用。
Dynamics of pinned membranes with application to protein diffusion on the surface of red blood cells.
作者信息
Lin Lawrence C-L, Brown Frank L H
机构信息
Department of Physics, University of California, Santa Barbara, California 93106-9510, USA.
出版信息
Biophys J. 2004 Feb;86(2):764-80. doi: 10.1016/S0006-3495(04)74153-3.
Abstract
We present a theoretical treatment and simulation algorithm for the dynamics of Helfrich elastic membrane surfaces in the presence of general harmonic perturbations and hydrodynamic coupling to the surrounding solvent. In the limit of localized and strong interactions, this harmonic model can be used to pin the membrane to intracellular/intercellular structures. We consider the case of pinning to the cytoskeleton and use such a model to estimate the macroscopic diffusion constant for band 3 protein on the surface of human erythrocytes. Comparison to experimental results suggests that thermal undulations of the membrane surface should play a significant role in protein mobility on the red blood cell.
摘要
我们提出了一种理论处理方法和模拟算法，用于研究在一般谐波扰动以及与周围溶剂的流体动力学耦合存在的情况下，赫尔弗里希弹性膜表面的动力学。在局部和强相互作用的极限情况下，这种谐波模型可用于将膜固定到细胞内/细胞间结构上。我们考虑将膜固定到细胞骨架的情况，并使用这样一个模型来估计人红细胞表面带3蛋白的宏观扩散常数。与实验结果的比较表明，膜表面的热起伏应该在红细胞上蛋白质的流动性中起重要作用。
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