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Localized striatal delivery of GDNF as a treatment for Parkinson disease.

作者信息

Kirik Deniz, Georgievska Biljana, Björklund Anders

机构信息

Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, BMC A11, 22184 Lund, Sweden.

出版信息

Nat Neurosci. 2004 Feb;7(2):105-10. doi: 10.1038/nn1175. Epub 2004 Jan 27.

DOI:10.1038/nn1175
PMID:14747832
Abstract
摘要

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Localized striatal delivery of GDNF as a treatment for Parkinson disease.局部纹状体递送胶质细胞源性神经营养因子作为帕金森病的一种治疗方法。
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Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes.将胶质细胞源性神经营养因子（GDNF）通过慢病毒基因传递至R6/2亨廷顿病小鼠纹状体中，未能减轻行为和神经病理学变化。
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