Kim Mi Kyung, Sasaki Satoshi, Sasazuki Shizuka, Okubo Shunji, Hayashi Masato, Tsugane Shoichiro
Department of Preventive Medicine, The Catholic University of Korea, Seoul, Korea.
Br J Nutr. 2004 Jan;91(1):81-90. doi: 10.1079/bjn20031024.
Antioxidant vitamins have been reported to be associated with an improvement in blood lipid profiles, but results are not consistent. The present study was designed to determine whether long-term vitamin C supplementation could alter serum lipid concentrations in subjects who completed a 5-year population-based double-blind intervention trial. A total of 439 Japanese subjects with atrophic gastritis initially participated in the trial using vitamin C and beta-carotene to prevent gastric cancer. Before and upon early termination of beta-carotene supplementation, 134 subjects dropped out of the trial; finally, 161 subjects assigned to the high-dose group (500 mg vitamin C/d) and 144 subjects assigned to the low-dose group (50 mg vitamin C/d) were studied. No favourable effect of vitamin C supplementation on serum concentrations of total cholesterol, HDL- and LDL-cholesterol, and triacylglycerol was observed, although high-dose vitamin C supplementation increased serum vitamin C concentrations substantially. Among women, the mean change in serum triacylglycerol decreased (-0.12 mmol/l, 95 % CI -0.32, 0.09) in the high-dose group, but increased (+0.12 mmol/l, 95 % CI 0.03, 0.22) in the low-dose group. In addition, the mean change in serum triacylglycerol among women with hypertriacylglycerolaemia was statistically significant (-1.21, 95 % CI -2.38, -0.05) after high-dose vitamin C supplementation. The 5-year vitamin C supplementation had no markedly favourable effects on the serum lipid and lipoprotein profile. However, our present results do not preclude the possibility that vitamin C supplementation may decrease triacylglycerol concentrations among women with hypertriacylglycerolaemia.
据报道，抗氧化维生素与血脂状况的改善有关，但结果并不一致。本研究旨在确定长期补充维生素C是否会改变完成了一项为期5年的基于人群的双盲干预试验的受试者的血清脂质浓度。共有439名患有萎缩性胃炎的日本受试者最初参与了使用维生素C和β-胡萝卜素预防胃癌的试验。在β-胡萝卜素补充剂提前终止之前和之时，有134名受试者退出了试验；最终，对161名被分配到高剂量组（500毫克维生素C/天）和144名被分配到低剂量组（50毫克维生素C/天）的受试者进行了研究。尽管高剂量补充维生素C可大幅提高血清维生素C浓度，但未观察到补充维生素C对血清总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和三酰甘油浓度有有利影响。在女性中，高剂量组血清三酰甘油的平均变化降低（-0.12毫摩尔/升，95%可信区间-0.32，0.09），而低剂量组则升高（+0.12毫摩尔/升，95%可信区间0.03，0.22）。此外，高剂量补充维生素C后，患有高甘油三酯血症的女性血清三酰甘油的平均变化具有统计学意义（-1.21，95%可信区间-2.38，-0.05）。为期5年的维生素C补充对血清脂质和脂蛋白状况没有明显的有利影响。然而，我们目前的结果并不排除补充维生素C可能降低患有高甘油三酯血症的女性的三酰甘油浓度的可能性。
